EFFECT OF CORVITIN ON OXYGEN TRANSPORT FUNCTION OF THE BLOOD AND GAS TRANSMITTERS IN ISCHEMIA-REPERFUSION OF THE LOVER LIMBS

Background. Ischemia-reperfusion of the lower limbs in atherosclerosis of their arteries is accompanied by impaired oxygen transport function (OTF) and the content gas transmitters (GT) of blood, which needs adequate correction. Purpose. To study the effect of corvitin on the parameters of OTF and GT of nitrogen monoxide and hydrogen sulfide in venous blood after revascularization of the lower limb in chronic atherosclerotic occlusion of the superficial femoral artery (SFA). Material and methods. Revascularization of the lower limbs in 103 patients was performed by loop endaterectomy from SFA. Patients of group I (n=52) received traditional medication support, II (n=51) - corvitin. The indices of OTFB and GT in the venous blood of the lower and upper limbs were determined before the operation, on the 3rd and 8th days after it. Results. The increase in the parameters of hyperoxemia, hypocapnemia and GT concentration in the postoperative period decreases with the use of corvitin. Conclusions. The use of corvitin reduces disturbances in OTFB and GT content during ischemia-reperfusion of the lower limbs.