Significant Neurological Manifestations During Pandemic COVID-19: A Review

The outbreak of coronavirus disease 2019 (Covid-19) was first identified in Wuhan, China, in early December 2019. In the past few months, it has spread rapidly all over the world. This pandemic is an unprecedented worldwide health crisis and has shaken the core of the medical health system. Covid-19 is caused by SARS-CoV-2, a highly infectious pathogen that is genetically similar to SARS-CoV. Apart from the typical respiratory symptoms, significant neurological manifestations are being recognized increasingly in Covid-19 patients involving the central and peripheral nervous system. It could be involved resulting in a wide variety of manifestations started from headache, dizziness, anosmia, dysgeusia, impaired consciousness, to specific neurological diseases such as cerebral infarction, meningitis, encephalitis, Guillain-Barr???? syndrome, and painful neuropathy. Novel clinical trial designs need to be considered since the virus has attacked the nervous system in various aspects. This paper aims to review the possibility of neurological symptoms involvement in Covid-19 in order to understand the pathogenesis potential of this virus in the nervous system. By doing so, we could manage and prevent the long term effects of Covid-19 patients with neurological manifestations.