Fibrodysplasia Ossificans Progressiva: A Case Report

Fibrodysplasia ossificans progressiva (Munchmeyer's disease, stoneman's disease, Myositis Ossificans Progressiva) is a very rare autosomal dominant genetic connective tissue disease, but most patients have a new mutation with a progressive ectopic ossification of muscle (intramuscular) or perimuscular connective tissue such as tendons or joint capsules. The osseous masses produced will form bridges that abnormally connect sections of the skeleton, causing disfiguration and normal motor function inhibition. We reported a 20-year-old female with few hard nodules on the back region which initially present as a painful soft mass on the back region. As the pain subsided, the mass hardened and also appeared in other parts of her back. Individuals are born usually following an uneventful gestation but the great toe abnormalities are almost invariably present at birth.These include hallux valgus, shortened great toes and sharpening of the first metatarsal bone. In the first decade of life, intermittent episodes of painful soft tissue swellings occur which progress to become the hard, bony lesions that characterize the disease. We decided not to do a biopsy or excisional surgery to prevent flaring up of the disease. Early diagnosis prevents catastrophic diagnostic and treatment procedures. The progressive nature of this disease is difficult to stop but we should delay it as much as possible by preventing muscle trauma, giving disease modifying agent and long-term physiotherapy to counter further disabilities which will eventually develop.