A Clinico-Pathological Study of Diabetic Foot with Special Reference to Role of Platelets Rich Plasma in Management of Diabetic Foot

Introduction: Diabetes mellitus is one of the most deceitful diseases that affect more than 371 million people all over the world in 2012; by 2030 this will rise to 552 million. Diabetic foot is a frequent site for complication in DM. Ulceration occurs as a result of trauma in the presence of neuropathy and/or peripheral vascular disease with infection as a secondary phenomenon following disruption of the protective epidermis. NS is isotonic and the most commonly used wound care solution due to lowest toxicity. PRP for enhancing wound healing was compared to conventional therapies. PRP enhances wound healing by either the barrier effect to prevent bacterial invasion into the wound or the growth factors stimulate wound healing. Aim: The aim of study will be a clinico-pathological study of diabetic foot with special reference to role of platelets rich plasma in management of diabetic foot. Materials and Methods: 90 patients with DIABETIC FOOT admitted to our institution between December 2018 to July 2020 were enrolled. Patient data was collected from attending, general surgery outdoor patient department, casualty and inpatient departments, irrespective of gender background socioeconomic status. Results: The study population was divided into three group, which indicates PRP group, PPP group and NS group respectively. The higher incidence of DM foot occurred in the age group of 41 to 50 years (32.2 %). Males (75.6 %) were affected more than female. Our study revealed a statistically significant reduction in ulcer size, depth and higher wound healing rate in the PRP group when compared to the other two groups. Conclusion: Our study revealed a statistically significant reduction in ulcer size, depth and higher wound healing rate in the PRP group when compared to the other two groups. Therefore the application of platelet-rich plasma in the management of diabetic foot ulcer is effective in improving the local growth factors.