The Comparison of the Effects of Dexmedetomidine and Magnesium Sulphate in Endoscopic Transnasal Transsphenoidal Resection of Pituitary Adenoma

Transsphenoidal resection of the pituitary tumours involves wide fluctuations in haemodynamic parameters such as hypertension and tachycardia due to local adrenaline infiltration, during nasal speculum insertion and during sphenoid resection. It is challenging for anaesthetist to provide bloodless field, heamodynamiac stability, surgical approach. In this study we compared the effects of dexmedetomidine and magnesium sulphate on the adequacy of hypotensive anaesthesia to produce bloodless field and decreasing the bloodloss in adult patients undergoing transsphenoidal resection of pituitary tumours. Using Boezaart surgical field grading and surgeons satisfaction score surgical field was graded. From our results we conclude that dexmedetomidine has advantage of causing controlled hypotension and reduction in heart rate with minimal blood loss compared to magnesium sulphate.