Evaluation of Hemodynamic Changes and Recovery Time in Patients under Going Laparoscopic Cholecystectomy - A Clinical Comparison between Desflurane and Sevoflurane

Objectives: To compare the following factors in two groups. The study population was randomly divided into two groups with 30 patients in each group denoted as group 'D' and group'S'between 20-70 years of age, undergoing laparoscopic cholecystectomy under general anaesthesia. 1) Group D- Receiving Desflurane 4%in 30 patients 2) Group S- Receiving Sevoflurane 2% in 30 patients. Parameters observed: Demographic parameters includes Age, Sex, Height, Weight. Hemodynamic parameters: HR, BP ? SBP, DBP, MAP, SPO2, End Tidal CO2 concentration. Recovery time: Time for spontaneous breathing, Eye-opening, Obeying commands, Handgrip, Recall of name. Assessments included will be recovery time to eye-opening, responseto commands, spontaneous breathing, recall of name, hand grip etc. Methods: In the present study 60 ASA grade I-II patients divided into two groups ?each group denoted as group 'D' and group'S'between 20-70 years of age, undergoing laparoscopic cholecystectomy under general anaesthesia. a) Group D- Receiving Desflurane 4%in 30 patients b) Group S- Receiving Sevoflurane 2% in 30 patients. Results: Age, sex, weight and the duration of surgery were comparable in both the groups.Both desflurane and sevoflurane-maintained intraoperative hemodynamics and the difference were statistically insignificant. The time to, extubation, recall of name, and handgrip were shorter in the desflurane group than the sevoflurane group. The difference was statistically significant. Mean response time to pain stimulus in sevoflurane was 5.3 min, and desflurane group was 4.6 min. The mean time for recall of name was 8.7 min in sevoflurane and desflurane group was 7 min. The time to recall of name was significantly more in sevoflurane. The mean time for handgrip was 8.2 min in the sevoflurane group and 6.9 min in the desflurane group. In our present study, the recovery characteristics are similar. The mean response to spontaneous movements in the sevoflurane group was 4.6 min, and desflurane group was 3.9 min though patients in the desflurane group had earlier spontaneous movements but not significant statistically. The mean duration for PARS greater than10 (post-anaesthesia recovery score of Aldrete and Kroulik) was 9.3 minutes and 11.1 minutes in Desflurane and Sevoflurane group respectivelyand it was statistically significant. The incidence of nausea and vomiting was 40% in the sevoflurane group and 50% in the desflurane group, the desflurane group had a higher incidence of nausea and vomiting in spite of using ondansetron as premedication.