Study of Efficacy and Success Rate of Single Dose Oral Mifepristone and Vaginal Misoprostol vs Vaginal Misoprostol alone for Second Trimester Termination of Pregnancy

Objectives: To compare the efficacy and the success rate of single dose oral Mifepristone plus vaginal Misoprostol versus vaginal Misoprostol alone for second trimester termination of pregnancy Study design: A prospective randomized control study Place and Duration of study: Department of Obstetrics and Gynaecology, OPD, DHIRAJ HOSPITAL, PIPARIYA, VADODARA , August 2018 to January 2019. Patients and Methods: 144 random cases attending the Obstetrics/Gynaecology OPD of Dhiraj hospital.Healthy women, fitting in the given below criteria requesting for termination of pregnancy between 12 to 20 weeks were selected. Results: Induction-abortion interval was between 3-10 hrs in study group compared to 4-15 hrs in control group. Study group required lower doses of misoprostol (600 mcg) compared to control group (1600 mcg).Completeness of abortion was higher in study group (98.6%) vs control group (84.7%). Conclusions: Pre-induction with Mifepristone in the second trimester termination of pregnancy is highly successful with lesser Induction abortion interval, lesser morbidity related to misoprostol, better patient compliance, and relatively shorter hospital stay. Keywords: Mifepristone, Oral misoprostol, Vaginal misoprostol, Second trimester Abortion