Dengue Complication in Children

Dengue is the most common arboviral disease transmitted globally and is also the most important one in terms of morbidity and mortality. It was estimated that annually over 50 million cases of dengue infection and about 400.000 cases of dengue hemorrhagic fever (DHF) occur in Asian countries. Of those with DHF, at least 90% are children younger than 15 years old. The dengue virus has four serotypes and maintains an infection cycle with Aedes aegypti mosquito. While Dengue is self-limited disease, but an increasing number of cases of Dengue infection have been associated with unusual manifestations, these include central nervous system, liver, cardiovascular, and very fatal conditions if patients do not get adequate and well management. The mechanisms leading to severe manifestations of dengue infections are still not completely understood but are likely to be multifactorial, include immune mechanism. This integrated view would like to emphasize the complication of dengue infection in children and how this unusual manifestation can be occurred.