To Compare and Evaluate the Efficacy of Esmolol and Labetalol in Attenuating Pressor Response to Laryngoscopy and Tracheal Intubation during General Anesthesia

BACKGROUND: Laryngoscopy and endotracheal intubation are associated with increased sympathomimetic response. Aim: To compare and evaluate the efficiency of Esmolol and Labetalol in attenuating the haemodynamic response to Direct laryngoscopy and endotracheal intubation. MATERIALS and METHODS: It is a Prospective, randomised, double-blind study in 50 patients of ASA grade I or II aged between 20?60 years of either sex who were scheduled for elective surgeries under general anaesthesia and divided into two groups (each group containing 25 patients). Group L(Labetalol) : patients received injection Labetalol , 0.25 mg/kg IV bolus diluted to 10 ml with 0.9% saline.Group E(Esmolol) : patients received injection Esmolol 0.5 mg/kg IV bolus diluted to 10 ml with 0.9% saline.All the selected patients are subjected to the same anaesthesia technique. HR, SBP, DBP and MAP were recorded before intubation, and then during intubation 0 minute, 1 min, 3 min, 5 min of intubation. RESULTS AND CONCLUSION: In lower doses, Labetalol provides better protection than Esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation