Serum Prolactin, Thyroid Stimulating Hormone and Thyroid Hormones (FT3, FT4) Concentrations in Female Patients with Infertility: An Institutional Study

Background: The prevalence of infertility is estimated between 12-14 %. Hormonal disorders of female reproductive system are comprised of a number of problems resulting from aberrant dysfunction of hypothalamic- pituitary-ovarian axis. Materials and Methods:The study was conducted on 50 women (age group 21?40 years) in Biochemistry Department of RIMS,Ranchi between March 2017- March 2018.Hormonal profile were done by enhanced chemiluminescent microparticle immunoassay method on ABOTT ARCHITECT i1000SR IMMUNOASSAY analyzer.50 fertile woman with similar age were enrolled as the controls. Results:There was a positive correlation between serum TSH and prolactin levels in the infertile subjects. Hyperprolactinemia was depicted in 57% of the infertile women while it was 7% in the control group. The infertile women with hypothyroidism had significantly higher prolactin levels when compared to the controls. Conclusion:Hyperprolactinemia with thyroid dysfunction may be a major contributory hormonal factor in female infertility patients and estimation of prolactin, FT3,FT4, and TSH should be included in the workup for patients with female infertility.