Correlation between Platelet Indices with Severity of Diabetic Peripheral Neuropathy based on Diabetic Neuropathy Symptom Score (DNS) in DM Tipe 2 Patients

Introduction: Diabetic peripheral neuropathy is one of the most common microvascular complications of Diabetes Mellitus and can worsen the life quality of the patients. Increased platelet size and volume occur in patients with risk factors for diabetes mellitus and diabetic neuropathy. Platelet indices is a parameter to measure the morphology and structure of platelets, including the number of platelets, the value of MPV, PDW and PCT. Method: This study is an analytical study with cross-sectional design aimed to determine the relationship between platelet index and severity of diabetic peripheral neuropathy based on DNS in diabetic type 2 patients in General Hospital of Haji Adam Malik Medan. The platelet indices was examined using a hematology analyzer Sysmex-XN. Results: Statistical analysis of the One-Way ANOVA test of 30 study subjects found that there was a significant difference in MPV values between moderate and mild DPN (p = 0.002) and between severe and mild degrees (p = 0.004). There was a difference between PDW with DPN severity (p = 0.001) but there was no significant difference between platelet counts and PCT with DPN severity (p = 0.503, p = 0.81). Conclusion: There is a significant relationship between MPV and PDW with the degree of Diabetic peripheral neuropathy, and there is no significant relationship between platelet count and PCT with the degree of diabetic peripheral neuropathy in Type 2 DM.