Antihyperglycemic Activity of the Crude Ethanolic Extract of Artocarpus heterophyllus Lam. (langka) Unripe Fruit against Alloxan-induced Hyperglycemia in Mus musculus (White Mice)

This study was conducted to determine the anti-hyperglycemic activity of the crude ethanolic extract ofArtocarpus heterophyllus Lam.(langka) unripe fruit using the method alloxan induced hyperglycemia in Mus musculus white mice. The different extract concentrations of A. heterophyllus were orally administered to the fasted hyperglycemic white mice. On the first, second and third hour after extract administration, fasting blood sugar (FBS) was measured and percent reduction in FBS were compared. The study showed that the crude ethanolic extract of A. heterophyllus unripe fruit exhibited anti-hyperglycemic activity at 5mg/20g (250mg/kg), 10mg/20g (500mg/kg), 15mg/20g (750mg/kg)on the third hour after the extract administration. Their results differ significantly to the negative control - dist. water (7.27+0.52) (P0.05). On the first and second hour, both 10mg and 15mg/20g bw of white mice exhibited anti-hyperglycemic activity but were not comparable to the positive control. The antihyperglycemic activity were concentration and time dependent. The best concentration that exhibited anti-hyperglycemic activity was at 15mg/20g bw of white mice and best time was on the third hour. The study demonstrated the anti-hyperglycemic activity of the crude ethanolic extract of A. heterophyllus unripe fruit at 5mg/20g, 10mg/20g, 15mg/20g against alloxan-induced diabetes in white mice. This study could serve as basis for future formulation of effective, low cost and locally available antihyperglycemic agent from A. heterophyllus unripe fruit subject for further study.