Effectiveness of Prophylactic Intravenous Granisetron for the Prevention of Nausea and Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study

Postoperative nausea and vomiting (PONV) are most common symptom after laproscopic surgeries. Various approaches have been proposed for the management of PONV but not without adverse effects. One of the potent drug granisetron has longer acting properties has introduced for the antiemetic treatment in chemotherapy patient and fewer studies in treating patient of laparoscopic surgeries. We undertake this study to evaluate the efficacy and safety properties of granisetron in prophylaxis PONV in laproscopic cholecystectomy. Aims: To study the efficacy of single prophylactic antiemetic therapy with granisetron@40g/kg I.Vin patients undergoing laparoscopic cholecystectomy. Material and Methods:- Total 120 patients of either sex age between 20 to 60 yrs posted for laparoscopic chloecystectomy with no history of PONV, non obesity ,non pregnant, no antiemetic intake for last 24 hour has been selected and standard protocol of general anesthesia were followed. Randomly patients received different doses of iv granisetron and placebo. Postoperatively, emetic episodes during the first 24 hours after anesthesia were recorded by nursing staff blind to which treatment the patients had received. The details of any adverse effects were noted throughout the study, whether obtained through general questioning of the patients by follow-up nurses, through observation by these nurses, or spontaneously mentioned by the patients. Results: - Efficacy to control postoperative nausea and vomiting were more when granisetron were used against pacebo. Conclusion:-Intravenous granisetron has effectiverole in treating PONV in laparoscopic cholecystectomy.