A Prospective Study to Correlate Glycosylated Hemoglobin (HBA1C) with Central Corneal Thickness (CCT) and Intraocular Pressure (IOP) in Type 2 Diabetic Patients

Purpose: To evaluate the correlation of glycosylated hemoglobin (HbA1c) with central corneal thickness (CCT) and intra ocular pressure (IOP) in type 2 diabetes mellitus patients. Methods: In a prospective study, 200 eyes of 100 patients of type 2 diabetes mellitus, in age group 30 to 80 years of either gender were evaluated for their HbA1c. The cohort was subdivided into 2 groups, with the cut off value of HbA1c of 8%. IOP measurements were obtained by Goldmann applanation tonometry. Pachymetry was done by NIDEK NT 530P and corrected IOP was calculated using Ehlers equation. The values were compared using correlation coefficient andt-test. Results: HbA1c values had positive correlation with CCT(r=0.27) and Corrected IOP(r=0.22).On comparison on t test, the p values were significant, less than0.03 and less than0.04 respectively. High CCT values and high IOP were found to have higher prevalence in group with HbA1cgreater than8%. Conclusion: In patients with type 2 diabetes, higher HbA1c values were positively related to higher CCT values and higher CIOPs, in a statistically significant way.