Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation using Esmolol and Lignocaine - A Comparative Study

AIM: To compare the efficacy of Esmolol Hcland Lignocaine Hcl in attenuation of hemodynamic response to Laryngoscopy and Endotracheal Intubation. MATERIALS and METHODOLOGY: A randomized, prospective, double-blind study in which 60 patients of ASA grade I or II aged between 20–60 years was conducted. LignocaineHcl 1 mg/kg and Esmolol Hcl 0.5 mg/kg were compared in attenuating the haemodynamic response to laryngoscopy and tracheal intubation in elective surgery under general anaesthesia. Patients were divided into two groups Group L(Lignocaine): patients receive injection Lignocaine, 1 mg/kg IV bolus diluted to 10 ml with 0.9% saline.Group E(Esmolol) : patients receives injection Esmolol 0.5 mg/kg IV bolus diluted to 10 ml with 0.9% saline. All the selected patients are subjected to the same anaesthesia technique. HR, SBP, DBP and MAP were recorded before intubation, and then during intubation 0 minute, 1 min, 3 min, 5 min of intubation. RESULTS: Systolic, Diastolic and Mean Arterial Pressures increased significantly in lignocaine group whereas it was attenuated more effectively in Esmolol group (pless than0.05). CONCLUSION: Esmolol is more effective than lignocaine in attenuating the haemodynamic response to laryngoscopy and tracheal intubation.