Utility of Immunohistochemical Markers in the Diagnosis of Small Cell Neuroendocrine Carcinoma Cervix - A Case Report

Neuroendocrine carcinoma (NEC) of cervix is an aggressive histological variant of cervical cancer accounting for about 1-1.5 % of all cervical cancers. High grade ( G3) neuroendocrine carcinoma are highly aggressive tumours and frequently present at an advanced stage. Immunuohistochemical staining for neuroendocrine markers provide support for diagnosis. The 5 year survival for small cell neuroendocrine carcinoma (SCNEC) of all stages reported to be 14-39 % with poorer survival in higher stage disease. The management of high grade neuroendocrine carcinoma may include specific neuroendocrine based systemic chemotherapy and radiotherapy including axial sites.