Anthocyanin Effect from Purple Ipomoea Batatas Decrease Formation CD40L, NFkB, and MDA in Inflamation Aterogenesis

Abstract The theory of atherosclerosis based on the inflammation caused by endothelial dysfunction, lipid infiltration, free radicals and inflammatory processes immunologic. The activate NFkB and induces the formation of proteins that enhance the immune system in atherosclerosis progression. Prevention efforts done through drugs or fitofarmaka, one of the herbs that contain anthocyanins which act as antioxidants. Antioxidants are substances that are capable of slowing or preventing the oxidation process. Oxidizing conditions can cause damage to proteins and DNA, cancer, aging, and other diseases. Anthocyanins here act as a free radical scavenger or exogenous antioxidants. Giving anthocyanin will lower cholesterol and reduce the formation of CD40 and TRAF2 complex will further decrease NFkB activity and also decrease the release of proinflammatory cytokines MCP-1 and increases contractility aorta. Purple Ipomoea batatas contains anthocyanins in levels high enough that the 110mg-210mg/100mg, considering the cheap price is also easy to grow plant is expected that this plant can be fitofarmaka for atherosclerosis. This research method using mice fed atherogenic diet for 65 days while the other group was given atherogenic diet along with dietary anthocyanins from purple cultivars Ipomoea varieties baatatas kawi mountain after examination of the complex CD40-TRAF-2 were formed, so that the activation of NFkB and MDA known effects of increased or decreased by the provision of anthocyanins from Ipomoea batatas purple varieties such. The expected result is a decrease in the formation of complex CD40-TRAF-2, NFkB, and MDA as evidence those anthocyanins from Ipomoea batatas able to be inhibiting the inflammatory process in atherosclerosis