Clinical Trial of Herbal Products Combination of Extract Gynura procumbens Leaves and Curcuma xanthorrhiza Rhizome as Anti-dyslipidemia

Various risk factors are involved in the incidence of cardiovascular disease, one of which is dyslipidemia. The objective of this study is to determnine the safety and efficacy of herbal product. This study used pre and post controlled group design, randomized controlled trial and open label by employing 50 subjects. The subjects were divided into 2 groups, i. e. simvastatin and herbal product. Group I received simvastatin with dose of 10 mg/day and group II received herbal product with dose of 3x10mL for 30 days. The efficacy of herbal product was evaluated with the ability to decrease total cholesterol, triglycerides, LDL, and increase HDL. The safety was evaluated with hematology, blood chemistry, and vital sign examinations performed before and after treatment. Data were analyzed using chi-square, paired T-test, independent T-test, Wilcoxon, and Mann-Whitney with a confidence level of 95 % (P less than0.05). The simvastatin group shows significant results (Pless than0.05) in decrease total cholesterol and LDL. The herbal group shows significant results (P less than0.05) in decreasing triglycerides, however, there was no effect on total cholesterol and LDL. Simvastatin and herbal product have the same efficacy (Pgreater than0.05) in increasing HDL. Simvastatin and herbal product show no adverse effect based on laboratory and clinical assay.