Clinical Outcome in the Treatment of Fungal Keratitis Receiving 1% Voriconazole and 5% Natamycin

Aim To conduct a therapeutic and exploratory clinical trial comparing the visual outcome following treatment with topical 5 % Natamycin vs 1 % topical Voriconazole for fungal keratitis. Method: 70 cases of initially suspected fungal keratitis patients were taken for treatment but 9 out of them did not come for follow up and excluded from the study. Two groups of minimum 30 patients each of isolated fungal keratitis were taken. One group received 5 % Natamycin and the other group received 1 % Voriconazole. Detailed history of the patients were taken followed by thorough general and ocular examination. Blood investigations including Gram stain, Koh and Culture and Sensitivity were done. Result: Final visual acuity at 3months follow up improved in both Voriconazole and Natamycin treated patients and the difference was found to be statistically insignificant with p value greater than 0.05. Conclusion: The resultant clinical outcome in terms of visual acuity are same in both the groups treated with 5 % Natamycin and 1 % Voriconazole.