Estimation of Albumin and Globulin in Pre and Post Radio-Therapeutic Patients: A Review

Cancer is the second deadliest disease worldwide that often results in death. Treatment of cancer causes many side effects and reduces the overall survival of the patients with a high cancer recurrence rate. Some chemical markers are used as a prognostic marker to predict the overall survival and cancer recurrence rate, but they cause many side effects. For resolving these problems, certain biological inflammatory markers are reported (Example C-reactive protein, Neutrophil-lymphocyte ratio, Body Mass Index, Albumin, Globulin, Albumin Globulin Ratio, Total bilirubin, Direct bilirubin, etc. ) that can reduce the side effects and can be used for the prediction of cancer recurrence and overall survival of the cancer patients. The current review is done to explore studies done to evaluate the side effects of radiotherapy and the role of serum protein parameters [1] especially Albumin Globulin Ratio (AGR) as indicator of radiotherapy side effects and whether it can be used as an inflammatory marker for prognosis of cancer patients undergoing radiotherapy. Method: We conducted a thorough electronic search by Cochrane, EMBASE and PubMed to identify relevant studies. Studies published on the role of serum protein patterns in cancer patients undergoing radiotherapy have been selected, analyzed and summarized. Results: A number of studies suggests the effect of radiotherapy on serum protein levels besides causing other tissue damages.