Evaluation of Antiepileptic Potential and Muscle Relaxant Activity of Solanum Lycopersicum Leaves in Rodents

Epilepsy is a collection of diverse disorders that together affect approximately 1 % of the general population. It is a paroxysmal behavioural spell generally caused by an excessive disorderly discharge of cortical nerve cells of the brain and can range from clinically undetectable (electrographic seizures) to convulsions. Epilepsy is usually controlled, but not cured, with medication. In the present study plant Solanum lycopersicum with a CNS activity, antiepileptic activity and muscle relaxant properties was selected and a herbal extract was prepared in ethanolic medium. Solanum lycopersicum (tomato) belongs to the family of nightshades or Solanaceae or nightshade family. Solanum lycopersicum was evaluated for its antiepileptic activity against pentylenetetrazole (PTZ), isoniazid (INH) induced chemical convulsions in mice. PTZ and INH were injected at the dose of 60 and 300 mg/kg, i. p. The mice treated with Solanum lycopersicum (400 mg/kg) showed significant protection (60 %) as compare to vehicle treated PTZ injected mice. All the drugs were given orally.200 and 400 mg/kg of EESL significantly reduced the time spent by the animals on revolving rod when compared to control (Pless than0.05). There was dose dependent increase in muscle relaxation, maximum with 400 mg/kg. In conclusion it is observed that Solanum lycopersicum has muscle relaxant and antiepileptic activity.