Efficacy of Mitomycin C in Dacryocystorhinostomy Operation: A Clinical Study - A Research Article

Aim: To study the effect of Mitomycin C (MMC) in Dacryocystorhinostomy (DCR) surgery. Materials and methods: The study included 101 cases of chronic dacryocystitis with or without complications over a period of one year which were divided into 2 groups; the control group with 51 cases where standard External Dacryocystorhinostomy (EXT-DCR) was performed and MMC group with 50 cases where 0.2 mg/ml MMC was used intra-operatively. A detailed history was taken and proper ocular examination was done. Blood investigations were done wherever indicated. A Rhinological examination by E. N. T specialist was done in all the cases in the Out Patient Department of E. N. T. . The operative techniques used were: Type I (Single Flap DCR), Type II (Double Flap DCR), and Type III (Periosteal anastomosis). Results: The success rate in Control group was 86.27 % and in MMC group was 96 %. The difference was statistically significant (p value less than0.05). Conclusion: Thus, intra-operative MMC is a safe and useful adjunct that helps to achieve long term success rate in EXT-DCR.