Relation of Acanthosis Nigricans to Glycated Hemoglobin (HbA1c) Test and Lipid Profile among Iraqis

Acanthosis Nigricans is a skin disorder characterized by hyperpigmentation, hyperkeratosis and papillomatosis with relationship to insulin resistance and metabolic changes. The aim of study to evaluate the role of acanthosis nigricans as a marker of Diabetes Mellitus and abnormal lipid profile by studying its relationship with age, ethnicity, anthropometry and other risk factors for T2DM in the Iraqi population. This study is a cross sectional study conducted in Dermatology Consultancy Clinic of Salahaldin General Hospital in Tikrit city during the period from 1st of November, 2018 to 31st of May, 2019 on samples of 50 patients with acanthosis nigricans and sample of 50m healthy adults were selected as controls. The acanthosis nigricans was diagnosed by the researcher clinically by clinical history and distinctive examination findings. glycated hemoglobin and Lipid profile were assessed for study participants. Mean serum triglyceride of acanthosis nigricans patients was significantly higher than the mean serum triglyceride of controls (p=0.01). Mean low density and very low density lipoproteins of acanthosis nigricans patients were significantly higher than mean that for controls. Although both of glycated hemoglobin levels for acanthosis nigricans patients and controls were within normal range; but glycated hemoglobin mean of acanthosis nigricans patients was significantly higher than that for controls (pless than0.001). In conclusion The acanthosis nigricans is a common predictor for metabolic disorders like diabetes mellitus.