FORMULATION AND EVALUATION OF FAST DISSOLVING SUBLINGUAL LISINOPRIL TABLETS
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.1, No. 6)Publication Date: 2014-12-18
Authors : Narasimhulu. Kurra; Chandrasekhara Rao Baru; Vidyadhara; Vanitha Prakash.K;
Page : 378-391
Keywords : KEY WORDS: Lisinopril; Sublingual; Insomnia;
Abstract
The present study was carried out to develop the Lisinopril sublingual tablets Lisinopril were available in 5 & 10 mg. In the present study 10 mg strength were prepared and evaluated for all the physical parameters evaluation and in-vitro drug dissolution studies. In the innovator preparation, Sodium Bicarbonate and Sodium Carbonate were used and the restriction was laid to the use of both the buffers. So, the generic version was prepared by using single buffer sodium carbonate. Sublingual Tablets of this drug is very essential to overcome the lack of compliance associated with higher dose of conventional oral swallowing tablets and also to protect the drug degradation from hepatic metabolism which can result in undesired pharmacological action. In vitro dissolution was carried out by using USP Apparatus Type-II at 75 rpm, using 6.8 pH phosphate buffer as dissolution medium recommended by office of generic drugs (OGD). The effect of diluents and superdisintegrants on the disintegration time and content uniformity was clearly studied in this research. Special emphasis was laid on the pH of the tablet as restriction was laid in using both the buffer systems. These sublingual tablets are used for treatment of insomnia. Sublingual tablets are developed because of their ease of administration and particularly insomniac patients will find great use of these sublingual tablets.
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Last modified: 2014-12-18 17:57:25