Evaluation of Effectiveness of Prophylactic Tranexemic acid for reducing Blood loss in Cesarean Section

BACKGROUND: Obstetrics blood loss is the major cause of maternal mortality and cesarean section accounts for 25-30 % of all deliveries. Delivery by cesarean section is associated with primary and secondary hemorrhage. Tranexemic acid is a synthetic derivative of aminoacid lysine that exerts its anti fibrinolytic effects by its reversible blockade of lysine binding sites on plasminogen molecules. OBJECTIVE: Main objective is to study the effectiveness of prophylactic parenteral Tranexemic acid (TXA) in reducing blood loss during and after elective lower segment cesarean section. METHODOLOGY: A Prospective randomized case control study conducted in the Dept of Obstetrics and Gynecology in Coimbatore Medical College on 150 women who underwent LSCS.75 of cases were given TXA before 20 minutes of skin incision. Other 75 were not given TXA. The amount of blood loss from the end of placental delivery to two hours post partum was measured along with vital parameters and adverse effects were compared among both the groups. RESULTS: TXA significantly reduces the amount of blood loss from the end of placental delivery to two hours post partum in the present study it was observed that blood loss in TXA group is 340 ml compared to control group where blood loss is about 450 ml which is statistically significant. No complications or side effects are reported among both the groups. CONCLUSION: TXA significantly reduces the amount of blood loss in cesarean section and is not associated with any side effects.