The Relationship between Metabolic Indicators in the First Trimester of Pregnancy and Gestational Diabetes: the Lipid Accumulation Products and Visceral Adiposity Index

Objective: The aim of this study was to research the place of lipid accumulation product (LAP; includes waist circumference (WC) and triglycerides) and visceral adiposity index (VAI; includes WC, triglycerides, and high-density lipoprotein), which are calculated in the first trimester for prediction of gestational diabetes mellitus (GDM). Methods: The LAP and VAI values of 134 women were calculated during the first prenatal visit, and they were followed until the 24th week of pregnancy. Comparisons were performed with regard to these values between women with a diagnosis of GDM (GDM group) and women in whom GDM was not detected (group with normal glucose metabolism). The correlations of these indices with metabolic parameters, anthropometric measurements, and demographic data were evaluated. Results: There were no differences in VAI or LAP index between the groups (p=0.12). VAI had positive correlation with weight gain, hip circumference (HC), insulin, and HOMA-IR. LAP exhibited positive correlation with age, body mass index, HC, total cholesterol, low-density lipoprotein, pregnancy, weight gain, parity, and HOMA-IR. Conclusion: A relationship between GDM development and VAI and LAP indices calculated in the first trimester could not be determined. Thus, these metabolic indices might not be a good indicator for GDM.