Study of Relation of Renal Functions in Chronic Liver Disease Patients

BACKGROUND: The inter relationship between liver disease and renal dysfunction was recognised since ages as this has been the considerable amoubt of research since then. kidney dysfunction in liver diseases may be due to different etiologies most of them with cirrhosis. Renal dysfunction in chronic liver disease follows a progressive course final being hepato renal syndrome. there is no clear explanation that fully defines the relationship between the diseased liver and disturbances in kidney function, though substantial progress is being made in recent years regarding research in this aspect. METHODOLOGY: The present study was carried out in the Department of General Medicine, GSL medical college/Hospital, Rajahmundry from NOVEMBER 1st-2015 to APRIL 30th-2017. Total 162 patients with chronic liver disease who satisfied inclusion and exclusion criteria were recruited in present study, with Cross-sectional study design. RESULTS: 162 patients with chronic liver disease were evaluated for renal dysfunction. The mean age of patients in the present study was 50.69 years. Majority of cirrhotics were in the age group of 50-59 years. The number of males were 144 (88.9 %) and the number of females were 18 (11.1 %). The most common cause of chronic liver disease was alcoholism which was seen in 109 (67.2 %) patients. Most of the patients were in group with GFR 30-60 ml/minute. Difference in the values of creatinine clearance calculated by using the Cockcroft Gault formula (CGF) and timed urine collection was found to be statistically significant (p value 0.001). CONCLUSION: Renal dysfunction is very common and is a major risk factor for increased mortality in patients with decompensated cirrhosis. The present study showed that standard measures of renal function, namely blood urea and serum creatinine should not be the only criteria to assess renal reserve in chronic liver disease, as they may seem normal even in gross renal dysfunction. Alcoholism was the most common cause of cirrhosis in the present study and also the most important modifiable causative factor for chronic liver disease and timed urine collections should be done routinely to assess renal reserve in advanced liver disease