Comparison of Two Different Doses of Dexmedetomidine in Decreasing the Extubation Response

BACKGROUND: Laryngoscopy, intubation and extubation is associated with sympathetic stimulation which results in hypertension and tachycardia. Drugs modulating the sympathetic response can be used during extubation to decrease the sympathetic response AIM: To compare of two different doses of dexmedetomidine in decreasing the sympathetic response. . METHOD: A hospital based Prospective, randomized, double blind study where a total of 66 patients undergoing surgery under general Anaesthesia in our hospital were randomly divided into 2 groups: Group-D1: Dexmedetomidine (0.25mcg/kg) group 33 patients; Group-D2: Dexmedetomidine (0.5mcg/kg) group 33 patients. The hemodynamic parameters, airway reflexes were assessed in different intervals of time and compared. RESULT: heart rate and systolic and diastolic blood pressure were significantly lower in D2 group (0.5 g/kg) as compared to D1 group (0.2 g/kg). Smooth extubation was reported in 93.9 % cases of D2 group as compared to 81.8 % in D1 group. Rough experience was seen in 18.2 % cases of D1 group as compared to 6.1 % in D2 group (p-0.25). Mean time for extubation was significantly lower in D2 group (136.7 vs 224.5 sec; p