Obstetrical Outcome of False Positive One Hour OGCT in Tertiary Care Hospital

OBJECTIVE: To evaluate the maternal and perinatal outcome of pregnancies with abnormal OGCT (oral glucose challenge test) and subsequent normal OGTT. METHODS: We performed a prospective observational study of 100 eligible pregnant women, over a period of 2yrs, between 1st January 2017 to 31st December 2018. Patients were screened for gestational diabetes mellitus (GDM) with the 1-hour 50-g OGCT at 24-28 gestational weeks. An isolated abnormal OGCT was defined as a result greater than or equal to 130 mg/dL followed by a normal 3-hour oral glucose tolerance test (OGTT). Clinical outcomes of pregnancies were studied in the selected population. RESULTS: The isolated abnormal OGCT cohort on average was younger, of higher parity, had a relatively higher body mass index and no associated risk factor. Pre-eclampsia19 % (19 cases) was the most common maternal complication. Caesarean section 25 % and difficult delivery 11 % rate were increased. Incidence of macrosomia was 3.7 %, overall perinatal morbidity was increased and 29 % needed NICU admission. CONCLUSION: An isolated abnormal OGCT is an independent risk factor for adverse perinatal outcomes. These suggest that minimal alterations in maternal carbohydrate metabolism may have a significant impact on the fetus and the patients with minimal alterations also require strict glycemic control to decrease the frequency of abnormal outcomes.