Role of Nuclear Abnormalities as a Biomarker in Early Diagnosis of Cervical Carcinoma

AIM: Identification of nuclear anomalies in exfoliated urothelial cells and comparison of this with those of from cervical smear. MATERIALS AND METHODS: This study included 500 cases with history of risk factors for cervical carcinoma. Cervical smear and urine samples were collected from each patient then processed and stained. Slides were observed under microscope to detect nuclear anomalies.500 cells were observed from each sample. RESULTS: The obtained data showed frequency of various nuclear abnormalities in cervical smears as well as urine samples in cases with high risk factors. CONCLUSION: Our study reveals that the identification of genotoxic effects as nuclear variations in urothelial cells can be used as a screening test in mass screening programs as it is an easy and reliable technique which can detect chromosomal instabilities rapidly.