Efficacy of Single Application of Doxycycline Hyclate in Treatment of Recurrent Aphthousstomatitis

Aim: The aim of the present study is to evaluate the efficacy of topical application of single dose of doxycycline hyclate 100mg tablet as a new therapeutic regimen in the treatment of minor RAU for pain reduction. Methods: The patients diagnosed with minor recurrent aphthous ulcers fulfilling the inclusion and exclusion criteria were enrolled. The study was conducted in the Department of ENT, H & NS, SKIMS-MC, Srinagar (J & K) India from January 2017 to January 2018 after approval by institutional ethical committee. This study included a total of 50 patients which were divided into two groups each of 25 patients. Group I: 25 patients receiving doxycycline hyclate 100 mg tablets (Doxt 100). Group II: 25 patients receiving placebo tablet. Results: The data indicated a significant reduction in pain in group A (i. e. , faster reduction in pain) compared with group B. On the third day, pain score was 3.80 in the study group and 5.65 in the control group [Table 1] with P value of 0.079 and it was found highly significant on the fifth day with a P value of