Dyslipidemia in Patients with Type2 Diabetes Mellitus

Context: Diabetes mellitusis one of the most diseases of life threading through its completing complexes such as dyslipidemia is one of the major risk factors for cardiovascular disease and metabolic disorders in diabetes mellitus. Aims: The primary objective of our study was to evaluate and assess the control of dyslipidemia in diabetes mellitus. The importance of the study was that the lipids disorders affect approximately 14 % of patients with diabetes mellitus whereas in non-diabetics the prevalence is approximately 6 %. Settings and Design: A case- control and hospital- based analytical study was conducted from January 2016 to November 2017 in Khartoum state. Methods: Two hundred Sudanese adult with T2DM were selected as test group and 100 apparently healthy volunteers as controls both groups were age and sex matched. Venus blood samples were after overnight fasting from all participants, the following parameters were surveyed: Total cholesterol (T. CH), Triglycerides (TG), High density Lipoprotein (HDL-C) and Low density Lipoprotein (LDL-C). Statistical Analysis Used: The quantitative variables were expressed as a mean and standard deviation and the qualitative variables incontinency tables. Students ttest and x2 tests were used to assess the differences between the groups. The level of significance was established as P less than 0.05. Results: means of serum levels of T. CH, TG, & LDL-C were statistically significant increased in diabetic patients in compression to controls (190.24 30.53) versus (164.63 13.37), p=0.00 (138.68 40.851) versus (100.28 24.869), p=0.02 and (122.37 39.39) versus (95.06 13.14) p=0.013 respectively. But result of HDL-C was statistically decreased in diabetic when compared to control group, ( 40.30 10.099) versus (53.95 8.170) p=0.021 respectively. Also these was moderate strong correlation between (T. CH, TG, HDL-C & LDL-C) and duration of diabetes (r 0.69, p=0.029), (0.69 p=0.010) (r 0.5, p=0.043) and (0.69 p=0.022) respectively. Conclusions: Serum level ofT. CH, TG, HDL-C & LDL-C is important tests for monitoring diabetic patients and prevent cardiac disorders. Early detection of dyslipidemia provides a prognostic value for the prediction of CVD in type 2 diabetes mellitus and the duration of disease should be consider.