Hb Q ? India: An uncommon hemoglobin variant diagnosed in two patients ? Case series

Hemoglobin Q-India (α 64 Asp→His) is an important member of the hemoglobin Q family, molecularly characterized by the replacement of aspartic acid by histidine. The first case of Hb Q-India was reported by Sukumaran in 1972 in a Sindhi family with associated β-Thalassemia. India is known as a country with a high prevalence of α - and β-thalassemia and different types of hemoglobinopathy. Many of these variants are yet to be identified. Here, we are reporting two cases of Hb Q- India diagnosed during premarital thalassemia screening.