Evaluate the Efficacy of Metformin and Glimepiride with Metformin in Patients with Type II Diabetes Mellitus

1. Introduction: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The hyperglycemia results from defects in insulin secretion, insulin action or both. The chronic hyperglycemia of diabetes is associated with specific chronic complications resulting in damage to or failure of various organs, notably the eyes, kidneys, nerves, heart and blood vessels. AIMS AND OBJECTIVES OF THE STUDY: To evaluate the efficacy of Metformin and Glimepiride with Metformin in patients with type II DM. METHODOLOGY Materials: Patient prescription form, Case history form, Blood Glucose levels Methods: The study was conducted over a period of six months. Sample size is 150 patients. Study conducted at Shree Shakthi Nursing Home, Yemmiganur. All Individuals eligible for participation were men and women between the ages of 45-85 years with type II Diabetes Mellitus by American Diabetes Association criteria who were diagnosed with type II DM. Exclusion criteria include pregnancy people and patients with coronary artery diseases. DISCUSSION: The study was carried for a period of six months at Sri Shakhti Nursing Home, Yemmiganur. Based on inclusion and exclusion criteria a total of 150 subjects were included.54 subjects were on monotherapy, 96 subjects were on dual therapy. CONCLUSION: In newly detected type II DM, Metformin alone is started along with lifestyle modifications. Good glycemic controls were achieved for patients whose sugar levels are not under controlled with metformin or for long standing diabetes patients dual therapy of metformin with glimipiride was started. Significant number of patients achieved good glycemic control.