Preparation, Characterisation and In-Vitro Evaluation of Mercapto Analogue of Dihydropyrimidone Derivatives for their Antimicrobial, Anti-Arthitic and Thrombolytic Activity
Journal: International Journal of Science and Research (IJSR) (Vol.8, No. 6)Publication Date: 2019-06-05
Authors : S. R. Jagtap; R. D. Gaikwad; B. B. Bahule; R. P. Yadav;
Page : 1274-1276
Keywords : Mercapto-dihydropyrimidones; cyclocondensation; antimicrobial activity;
Abstract
In the present paper, we wish to report the synthesis of mercapto- dihydropyrimidone derivatives starting from readily available reactants, reagents and catalysts. We have successfully carried out the cyclocondensation reaction of aromatic aldehydes, thiourea and ethyl cyanoacetate in presence of sodium carbonate. Yields of these derivatives are high and the crude products can be purified either by column chromatography or recrystallisation techniques. Finally they were characterised by IR, PMR and CMR spectroscopy. The mercapto- dihydropyrimidones were tested positive for their antimicrobial activity. They were also found to exhibit invitro-anti-arthtic and thrombolytic activity.
Other Latest Articles
- Effectiveness of Self Instructional Module (SIM) on Knowledge Regarding Polycystic Ovarian Syndrome (PCOS) among Late Adolescent Girls (17 to 19 years) in Selected Colleges at Gurugram, Haryana
- A Study to Assess the Effectiveness of Structured Teaching Programme on Knowledge and Attitude Regarding Alcohol Withdrawal Syndrome among Family Members of Alcoholic Clients at Selected Hospital in Jalgaon
- Periodic Variations of Lablab purpureus Productivity Harvested at Different Growth Stages: A Case Study in Mid Northern Uganda
- Aquaponics - Self Sustainable Ecosystem
- Effect of Addition of Fly Ash on Workability of Concrete
Last modified: 2021-06-28 18:17:02