Effect of Loratadine Tablets on the Symptomatic Control of Seasonal Allergic Rhinitis in Adults Challenged with Ragweed Pollen in the Environmental Exposure Unit in Compassion with Azelastine Nasal Spray with Loratadine Tablets, Cetirizine Tablets, and Pl

Loratadine is a second-generation, non-sedating antihistamine used for the relief of allergic rhinitis symptoms. Previous studies reported that when loratadine was encapsulated, the onset of action for symptom relief was 180 min. However, unmodified loratadine tablets were not evaluated at that time. Using data from a previously published Environmental Exposure Unit (EEU) study comparing azelastine nasal spray with loratadine tablets, cetirizine tablets, and placebo, this post hoc analysis determines the onset of action of loratadine tablets, by analyzing the total symptom score for the relief of nasal and ocular seasonal allergic rhinitis (SAR) symptoms.