Correlation between Antiphospholipid antibodies and Recurrent Spontaneous Miscarriage in Saudi Women

Objective: To examine the association between antiphospholipid antibodies and gestational age of abortion and duration post abortion in Saudi women living in Western region of Saudi Arabia (Makkah) in order to consider the interactive association with major demographic factors. Materials and Methods: In this free-living population study blood samples were collected from 100 females who had history of spontaneous recurrent abortion as case group and 100 pregnant healthy women as control group ages ranged between 22 and 40 years, with a mean age of 31.4 � 12.69 years. Serum antiphospholipid antibodies were measured. Results: Average rate of antiphospolipid antibodies in the serum of case group compared with the control group indicated no significant statistical difference. In case group the number of miscarriages were more, mean of antiphosopolipid antibody levels were also higher. Mean antiphospholipid antibodies rate was greater with increasing gestational age at time of first miscarriage. Almost mean antipospholipid antibodies in all patients remained in high level just in first 4 years with any number of miscarriages and 4 years later, antibodies began to fall. Conclusion: The results of the present study demonstrated that antiphospholipid antibodies based on number of miscarriages and gestational age of miscarriages were increased. More over mean antipospholipid antibodies in all patients remained in high level just in first 4 years post miscarriage and then began to fall. However, well-designed diagnostic studies are needed to estimate the true association between other specific autoantibodies and recurrent miscarriage through epidemiological studies with a larger sample size, including different age groups and populations.