Desloratadine Microemulsion Based Solid Lipid Nanoparticles
Journal: International Journal of Science and Research (IJSR) (Vol.8, No. 9)Publication Date: 2019-09-05
Authors : Varsha Dute; Vijay Mahajan; Amol Deshmukh;
Page : 1274-1287
Keywords : Solid lipid Nanoparticles; Microemulsion; SEM; XRD; Spray drying;
Abstract
In this study, novel and main objective of this research work was to formulate and evaluate the Microemulsion Based Solid lipid Nanoparticles. Desloratadine o/w microemulsion based SLN was prepared to enhanced solubility. Desloratadine saturated solubility determined in different oils, Surfactants and co-surfactants. Sunflower oil, as oily phase and Tween 80 as surfactants and co-surfactants Propylene glycol used for pseudo ternary phase diagrams was constructed to identify the microemulsion regions. Evaluation Drug content, Drug release, Emulsification time, Visual inspection. pH, Particle size. Solid SLN � DSC, XRD, SEM, FT-IR, Refractive index, Drug Release.
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