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Effects of Uremia on White Blood Cells, Platelets and Coagulation Parameters: A Single-Centre Ambispective Study

Journal: International Journal of Science and Research (IJSR) (Vol.8, No. 9)

Publication Date:

Authors : ; ;

Page : 1524-1527

Keywords : Chronic kidney disease; White blood cells; Platelets; Bleeding time; Prothrombin time and Activated partial thromboplastin time;

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Abstract

Our study aimed at analysing the total number of chronic kidney disease (CKD) patients with abnormalities in white blood cells and coagulation parameters. A total of 300 patients were analysed in an ambispective, correlation study. Neutrophilia was observed in 45 % of cases and 77 % of them were in stage 5 CKD without infections, and toxic change were observed in 55 %. Prolongation of PT was seen in 16.1 % of cases and in this group, 33 % of them were being treated for sepsis. Similarly, a prolonged aPTT was observed in 14.7 % of cases and among them 34 % had sepsis. Conclusion: Alteration in the coagulation profile and leucocytes number and morphology can be due to infections because of defects in immune system or interference by uremic toxins.

Last modified: 2021-06-28 18:24:51