Foetomaternal Morbidity and Foetal Outcome of Cytomegalo Virus Seropositive Pregnant Women: Experience from Bangladesh

Introduction: One of the betaherpesvirinae subfamily of the herpes viruses is Cytomegalovirus (CMV). Most common cause of congenital infection is the CMV. On the other hand congenital CMV is most commonly identified as viral complication of mental retardation and one of the leading nongenetic causes of neurosensory hearing loss. Satistically in developed countries, congenital CMV infection occurs in 0.3 % to 2.4 % of all live births. One of the most dominant congenital viral infection is CMV and by this way, causes enormous disease burden on newborn infants. Seroprevalence in the mother antibodies to CMV due to the exposure of CMV before pregnancy, is now in a days the most important protective factor against congenital CMV disease. The aim of this study was to identify Foetomaternal Morbidity and Foetal Outcome of Cytomegalo virus Seropositive Pregnant Women. Objectives: This study was design to to detect foetomaternal morbidity of Cytomegalo virus seropositive pregnant women and to detect foetal outcome of Cytomegalo virus seropositive pregnant women. Materials and Methods: This cross sectional study was carried out in the Department of Microbiology, Armed Forces Institute of Pathology and Department of Medicine, CMH Dhaka from June 2016 to May 2017 and Study population were women of (21-50) years who were referred to Armed Forces Institute of Pathology for CMV test. Results: Among 567 pregnant women, age 21-50 yrs 33 cases found positive for IgM of cytomegalo virus, which is 6 %. Among 33 IgM positive for CMV cases 30 children was born alive (91 %), there were 3 miscarriages within 1st trimester of pregnancy which is 9 % of all cases. Conclusion: CMV is an important cause of congenital infection and can result in significant perinatal morbidity and health care expense. Seroprevalence in the mother antibodies to CMV due to the exposure of CMV before pregnancy, is now in a days the most important protective factor against congenital CMV disease. Universal neonatal screening has been recommended to detect those at risk of congenital abnormalities.