ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Prolific Drug Discovery Human ?-Hemoglobiopathies ? Thalassemia - Sickle Cell Anemia - Anemic Condition

Journal: International Journal of Science and Research (IJSR) (Vol.8, No. 11)

Publication Date:

Authors : ;

Page : 1344-1347

Keywords : Hemoglobin; Sickle Cell; Anemia; Bioactive; Chemistry; Beta Thallasemia;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

The Thalassemia are the commonest monogenic disorders in the world, and globally it is estimated that there are 270 million carriers, of which 80 million are carriers of -Thalassemia. -Thalassemia is widespread in the Mediterranean, Southeast Asian, African, and Middle East populations. The mean prevalence of this disease in India is 3.3 %. It has become much more common recently in northern and central Europe, including Germany, due to immigration. The Thalassemia refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of one or more of the globin chains (, , , , , , and). -thalassemia occurs when there is a deficiency of -globin, which is typically caused by a direct down-regulation in the synthesis of structurally normal b chains. However, a thalassemia phenotype can also arise from structural b chain variants if they are synthesized at a reduced rate. The most severe form of Thalassemia is characterized by the complete absence of HbA (22) which results from the inheritance of two homozygous -thalassemia alleles. This normally presents as a life-threatening anemia requiring blood transfusions from infancy. Inheritance of single -thalassemia alleles is presented by a clinically asymptomatic condition, but may show a mild anemia.

Last modified: 2021-06-28 18:31:37