A Comparative Study of Effect of Etomidate, Propofol and Etomidate Plus Propofol Induction on Hemodynamic Response to Endotracheal Intubation: A Prospective Randomized Controlled Study

Aim: The primary objective of this current study was to compare the efficacy of three different anaesthesia induction approach (Inj. Etomidate, Inj. Propofol, and Inj. Etomidate plus Inj. propofol) in maintaining hemodynamic stability during induction followed by endotracheal intubation in patients undergoing elective surgeries. Material and methods: Total 90 patients, aged 16 to 65 years of both sex and ASA physical status I or II scheduled for elective surgeries under general anaesthesia were taken for this present study. After taking both written and informed consent, the patients were randomly placed into three groups. Group E with Inj. Etomidate (0.3 mg/kg) intravenously, Group P induced with Inj. Propofol (2.5 mg/kg) intravenously, and Group PE with Inj. Etomidate (0.2 mg/kg) plus Inj. Propofol (1.5 mg/kg) intravenously. Patient's Heart rate (HR), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Mean arterial blood pressure (MAP), and Saturation percentage of Oxygen (SPO2) were noted at different time interval. 2 Results: In all the study groups Heart rate (HR) decreases after induction, and it is more in group P when compared to group E and PE. Among all the three groups MAP decreases after induction, and it was more in group P than group E and PE. MAP increases significantly at 1 min after intubation in all the three study groups, but this increase is not sustained and returned to baseline in group E and PE. Conclusion: Hemodynamic stability is better with the combination of etomidate plus propofol than that of etomidate alone at 1 min after intubation, even though etomidate is equally stable at other points of time. The combination has proved to be significantly better than the administration of etomidate or propofol individually.