Effects of Mineral Separation by Time and Enteric Coating Mechanism for Calcium and Iron Absorption in Mammalia

It is best-known that in rats and humans, the metallic element markedly inhibits the absorption of iron once each mineral is present within the little intestine. The interaction between iron and Ca was studied in two species, rats and dogs. feminine rats were orally treated with six mg calcium as metallic element citrate-malate followed by seventy ug iron as metal sulfate labeled with [59]Fe. Doses were separated by zero to a hundred and eighty min. Iron absorption was measured by the victimization of the whole-body atom retention technique. we have a tendency to determined that iron and calcium should be separated by a minimum of one hour to forestall a negative impact of calcium on iron absorption. This info was wont to style tablets containing iron (radiolabeled with [59]Fe) and Ca. Iron tablets were created by enteric coating iron with or while not ascorbic acid (attention of non-heme iron absorption). The enteric coat delayed the discharge of iron into the little internal organ by preventing iron dissolution within the abdomen for a minimum of one hour. Iron absorption from these tablets and uncoated tablets was measured in dogs victimization an assay of [59]Fe incorporation into hemoproteins. Calcium inhibited the absorption of uncoated iron-ascorbic acid by concerning 50~. However, once the enteric-coated iron-ascorbic acid tablets were dosed with metallic element tablets, iron absorption wasn't inhibited. We conclude that Ca inhibits iron absorption in rats and dogs and that this inhibition may be overcome once the 2 minerals square measure separated by a minimum of one hour, which can be achieved by enteric coating the iron supply.