A Comparative Evaluation of Efficacy of 1.2% Atorvastatsin and 1.2% of Rosuvastatsin with Platelet Rich Fibrin in Intaosseous Alveolar Defects: A Randomized Clinical Trial

Aim: To determine the effectiveness of treating intra osseous defects with open flap debridement followed by placement of 1.2 % Atorvastatin (ATV) gel and 1.2 % Rosuvastatin (RSV) gel alone and mixed with autologous platelet rich fibrin (PRF). Materials and methods: 24 subjects with 82 periodontal intra osseous defects were selected and open flap debridement was carried out. Following 20 sites received 1.2 % ATV gel (group I), 20 sites received 1.2 % RSV gel (group II), 20 sites assigned to group III received 1.2 % ATV gel mixed with PRF and group IV comprising of 20 sites received 1.2 % RSV gel mixed with PRF. Site specific Plaque index, papillary bleeding index (PBI), probing depth reduction (PD) and clinical attachment level (CAL) gain and radiographic defect depth reduction was assessed at baseline 3, 6 and 9 months intervals. Statistical Analysis used: Kruskal Wallis test and Mann Whitney U test Results: Comparing the results at 9 month interval all the groups has shown a significant reduction in PD reduction and CAL gain from baseline. The inter group analysis have shown no statistical significant difference in group I, II, III and IV in both clinical and radiographic parameters at a 9 months interval. Conclusion: The present study establishes a marked improvement in the clinical parameters and radiographic outcomes were noted with both 1.2 % ATV gel and 1.2 % RSV gel alone and Autologous PRF coated with 1.2 % ATV gel and 1.2 % RSV gel in the treatment of intra osseous defects.