Vitamin E Modulates the Oxidant-Antioxidant Imbalance of BPA induced Oxidative Stress in Albino Rats

Bisphenol A ( BPA) is one of the worlds highest production volume chemicals used in polycarbonate plastics in many consumer products and epoxy resins lining food and beverage containers. Study on the oxidative stress and antioxidant enzyme defense system in BPA induced rats blood sample revealed an augmented oxidative stress due to BPA level in rat blood sample and decreased antioxidant enzyme defense which might decrease the blood pumping efficiency and leading to the probable increase of oxidative stress in blood. the supplementation of vitamin E is an important lipid soluble antioxidant invivo, and it is presumed that its principle role is to protect membrane lipids from lipid peroxidation invivo, by scavenging lipid alkoxy or peroxy radicals which are capable of ing hydrogen from adjacent polyunsaturated lipid molecules to propagate a lipid peroxidation reaction and thus prevent the serum damage due to oxidative stress.