Comparison of Intravenous Fentanyl vs Dexmedetomidine in Attenuation of Pressure Response during Laryngoscopy and Endotracheal Intubation

Background Haemodynamic changes during laryngoscopy and endotracheal intubation is usually transient, variable and unpredictable and proved to be fatal in patients with hypertension, coronary artery disease or intracranial hypertension which may lead to left ventricular failure, myocardial ischemia and cerebral hemorrhage. To& #039, blunt& #039, this pressure response, various pharmacological agents have been tried which include adrenergic blockers, vasodilators, calcium channel blockers, lignocaine and opioids. We aimed to study comparative effect of i. v. Fentanyl vs Dexmedetomidine in attenuation of the pressure response during laryngoscopy and endotracheal intubation. Objective This study was carried out to compare the effectiveness of Fentanyl vs Dexmedetomidine in attenuating the pressure response associated with laryngoscopy and endotracheal intubation. Materials and methods The study was carried out on 40 patients belongings to ASA grade I and II, aged 15 to 65 years, including either gender, scheduled for elective surgical procedures under general anaesthesia. After ethical committee clearance, patients were divided into two groups. Group F Inj. Fentanyl 2 mcg/kg diluted in 10 ml saline intravenously, Group D Inj. Dexmedetomidine 0.5 mcg/kg diluted in 10 ml saline intravenously. Study drugs were administered 10 minutes before laryngoscopy and intubation. Hemodynamic parameters like heart rate, systolic, diastolic and mean arterial blood pressure, spo2 were measured at 2 minutes interval. Result Increase in heart rate, systolic and diastolic blood pressure were more observed in fentanyl group and were statistically significant as compared to dexmedetomidine group fallowing administration of study drug. Conclusion We conclude that i. v. Dexmedetomidine (0.5mcg/kg) is superior to i. v. Fentanyl (2 mcg/kg) as far as sympathetic stimulation concern