A Comparative Study of Attenuation of Propofol Induced Pain by Lignocaine, Ondansetron, Dexamethasone and Cold Propofol per se.

Background Pain on injection of propofol is a common problem. Aim of this study was to compare the efficacy of lignocaine, ondansetrone, dexamethasone and cold propofol per se as a pretreatment drug for attenuation of pain due to propofol injection. Materials and Methods Fifty two ASA and patients were randomly assigned into four groups (13 in each). Group O received 0.1mg/kg ondansetron, Group L received 0.5mg/kg lignocaine, Group D received 0.1mg/kg dexamethasone, Group T received propofol 1 % at 4 2mg/kg. Mid forearm was occluded manually before injection of pre-treatment drug and released after 1 min and then propofol was injected over 5 sec. Patients were observed and questioned 15 sec later if they had pain and pain was assessed using four point scale0 = no pain, 1 = mild pain, 2 = moderate pain, 3 = severe pain. ResultThe incidence and intensity of pain were significantly less in all groups. We observed mild to moderate pain in Group L, O, D, and T were 31 %, 54 %, 46 % and 77 % respectively. The incidence of score 0 was significantly higher in Group L (70 %) and Group D (54 %) and Group O (46 %) than Group T (23 %) (p