Synthesis of Some New Nucleoside Analogues from Theobromine via Schiff Base
Journal: International Journal of Science and Research (IJSR) (Vol.7, No. 3)Publication Date: 2018-03-05
Authors : Thanaa M. Al-Mouamin; Sumaya J. Abid;
Page : 58-66
Keywords : Theobromine; Schiff base; anti-microbial;
Abstract
Of the approximately 40 antiviral drugs formally approved for use, half of them are nucleoside or nucleotide analogues. So new derivatives of nucleoside analogues were obtained from the work that was conducted in this research. Firstly, the reaction of theobromine was reacted with sodium hydride in DMF at (0 C) to give it& #039, s salt, then the produced salt was reacted with chloroacetyl chloride to produce 1- (chloro acetyl) theobromine [3]. Thereafter, compound [3] was reacted with hydrazine hydrate to give 1- (1-acetohydrazide) theobromine [4] then reacted with a different substitution of an aromatic aldehyde in absolute ethanol to give Schiff& #039, s bases derivatives [5-12]. The reaction of compounds [5-12] with 1, 23, 4-Di-O-isopropylidene- - D- galactopyranosyl bromide [2] forming blocked nucleoside analogues [13-20]. Deblocking of these nucleoside using in 50 % aqueous acetic acid to give the free nucleoside [21-28]. The new prepared compounds were identified by [FTIR, 1H-NMR and 13C-NMR] and their physical properties were measured. Furthermore, we have evaluated the effect of some prepared compounds on some bacterial and fungal strains.
Other Latest Articles
- The Effect of Marketing Mix and Brand Image on Customer Loyalty at Premixed Mortar
- Regional Competitiveness of Healthcare Services in Saudi Arabia
- The Improvement of Students? Cognitive Achievement Trough Flowchart Visual Media
- Open Mesh Repair for Ventral Hernias ? Onlay or Preperitoneal: Analysis of a Young Surgeon's Dilemma
- Studies on Utilization of Ragi for Preparation of Malted Ragi Cookies
Last modified: 2021-06-28 19:05:38