COMPARITIVE STUDIES ON THE PHYSICOCHEMICAL PROPERTIES AND DISSOLUTION OF MARKETED CIPROFLOXACIN TABLETS

Ciprofloxacin is a second generation fluoroquinolone derivative acts by inhibiting bacterial DNA gyrase (TopoisomeraseII) used for the treatment of bacterial gastroenteritis, respiratory tract infections, controlling bronchitis and pneumonia caused by Gram negative bacteria. In this study the physicochemical properties and dissolution was carried out for three brands of marketed ciprofloxacin tablets. The present work is comparing the physiochemical evaluation (Weight variation, Hardness, Thickness and Diameter, Friability, Disintegration and Dissolution), release characteristics of manufactured Ciprofloxacin tablets. Here we enclosed the comparison results of three brands of marketed Ciprofloxacin tablets and Trend charts. Key words: Ciprofloxacin, physicochemical properties, dissolution, Trend charts