Mesenchymal Stem Cell Therapy for Burn Injury: Literature Review

Stem cell therapy has been considered as the final frontier therapy to treat various disease including wound that caused by burn injury. Despite its systemic effect, severe burns raise a great challenge to gain a good wound healing process. Using stem cells in promoting burn wound healing gives some advantages such as they can enhance the healing process of the burn wounds and decrease the inflammation process with minimum scar progression and fibrosis. Mesenchymal stem cells (MSCs) are commonly used to treat burn wound due to their features to be able to differentiate into cells within the mesodermal, ectodermal and endodermal lineage and are abundantly available in human tissue. This review article gives an insight about physiology of burn wound and skin regeneration, characteristic and source of MSCs as well as the use of MSCs as skin wound therapy.